Metoclopramide

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2404
R3055		 Ashkenazi-Hoffnung, 2013 Late preterm birth (34-36 weeks gestation) at least 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 0.07 [0.00;1.42] C 0/28   5/28 5 28
ref
S2397
R3004		 Pasternak, 2013 Preterm birth (< 37 weeks of gestation) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.98 [0.93;1.04] 1,852/36,839   7,213/146,908 9,065 36,839
ref
S2395
R2975		 Matok, 2009 Preterm (< 37 wk) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.15 [0.99;1.34] 219/3,458   4,593/78,245 4,812 3,458
ref
S2751
R3654		 Asker, 2005 Preterm birth (<37 completed weeks) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.94 [0.77;1.14] 54/1,166   33,653/665,572 33,707 1,166
ref
S2393
R2961		 Berkovitch, 2002 Prematurity (<37 wk) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No Matched 3.37 [1.12;10.12] 13/158   4/164 17 158
ref
S2407
R3065		 Sorensen, 2000 Preterm (less than 37 weeks) 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.02 [0.60;1.70] 17/295   793/13,327 810 295
ref
Total 6 studies 1.03 [0.89;1.20] 48,416 41,944
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ashkenazi-Hoffnung, 2013Ashkenazi-Hoffnung, 2013 0.07[0.00; 1.42]5280%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.98[0.93; 1.04]9,06536,83939%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Matok, 2009Matok, 2009 1.15[0.99; 1.34]4,8123,45829%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Asker, 2005Asker, 2005 0.94[0.77; 1.14]33,7071,16624%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Berkovitch, 2002Berkovitch, 2002 3.37[1.12; 10.12]171582%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Sorensen, 2000Sorensen, 2000 1.02[0.60; 1.70]8102957%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (6 studies) I2 = 58% 1.03[0.89; 1.20]48,41641,9440.010.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.89; 1.20]48,41641,94458%NAAshkenazi-Hoffnung, 2013 Pasternak, 2013 Matok, 2009 Asker, 2005 Berkovitch, 2002 Sorensen, 2000 6 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.04[0.91; 1.18]48,41141,91655%NAPasternak, 2013 Matok, 2009 Asker, 2005 Berkovitch, 2002 Sorensen, 2000 5 exposed to other treatment, sickexposed to other treatment, sick 0.07[0.00; 1.42]528 -NAAshkenazi-Hoffnung, 2013 1 Tags Adjustment   - No  - No 0.65[0.02; 26.23]2218682%NAAshkenazi-Hoffnung, 2013 Berkovitch, 2002 2   - Yes  - Yes 1.01[0.93; 1.10]48,39441,75827%NAPasternak, 2013 Matok, 2009 Asker, 2005 Sorensen, 2000 4 MatchedMatched 3.37[1.12; 10.13]17158 -NABerkovitch, 2002 1 All studiesAll studies 1.03[0.89; 1.20]48,41641,94458%NAAshkenazi-Hoffnung, 2013 Pasternak, 2013 Matok, 2009 Asker, 2005 Berkovitch, 2002 Sorensen, 2000 60.010.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.53.61.8050.000Ashkenazi-Hoffnung, 2013Pasternak, 2013Matok, 2009Asker, 2005Berkovitch, 2002Sorensen, 2000

Asymetry test p-value = 0.7170 (by Egger's regression)

slope=-0.0184 (0.0586); intercept=0.3626 (0.9318); t=0.3891; p=0.7170

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.04[0.91; 1.18]48,41141,91655%NAPasternak, 2013 Matok, 2009 Asker, 2005 Berkovitch, 2002 Sorensen, 2000 5 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.07[0.00; 1.42]528 -NAAshkenazi-Hoffnung, 2013 10.510.01.0