Domperidone

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2835
R13247		 Cottin (Control exposed to other treatments), 2015 Major malformations 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 3.95 [0.19;83.36] C
excluded (control group) 		2/112   0/87 2 112
ref
S2825
R13248		 Cottin (Controls unexposed, disease free), 2015 Major malformations 1st trimester prospective cohort unexposed, disease free Adjustment: No 0.65 [0.13;3.28] C 2/112   6/221 8 112
ref
S2740
R13246		 Choi, 2013 Gross malformations 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 1.80 [0.40;9.00] 3/120   3/212 6 120
ref
Total 2 studies 1.10 [0.36;3.39] 14 232
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cottin (Controls unexposed, disease free), 2015Cottin, 2015 1 0.65[0.13; 3.28]811248%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Choi, 2013Choi, 2013 1.80[0.40; 9.00]612052%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.10[0.36; 3.39]142320.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.10[0.36; 3.39]142320%NACottin (Controls unexposed, disease free), 2015 Choi, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.10[0.36; 3.39]142320%NACottin (Controls unexposed, disease free), 2015 Choi, 2013 2 Tags Adjustment   - No  - No 1.10[0.36; 3.39]142320%NACottin (Controls unexposed, disease free), 2015 Choi, 2013 2 All studiesAll studies 1.10[0.36; 3.39]142320%NACottin (Controls unexposed, disease free), 2015 Choi, 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2835

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.10[0.36; 3.39]142320%NACottin (Controls unexposed, disease free), 2015 Choi, 2013 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.95[0.19; 83.36]2112 -NACottin (Control exposed to other treatments), 2015 10.510.01.0