Domperidone

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2835
R3806		 Cottin (Control exposed to other treatments), 2015 Elective terminations of pregnancy 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.64 [0.19;2.15] C
excluded (control group) 		5/124   6/97 11 124
ref
S2825
R3801		 Cottin (Controls unexposed, disease free), 2015 Elective terminations of pregnancy 1st trimester prospective cohort unexposed, disease free Adjustment: No 1.12 [0.37;3.40] C 5/124   9/248 14 124
ref
Total 1 studies 1.12 [0.37;3.40] 14 124
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cottin (Controls unexposed, disease free), 2015Cottin, 2015 1 1.12[0.37; 3.40]141240%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.12[0.37; 3.40]14124 -NACottin (Controls unexposed, disease free), 2015 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.12[0.37; 3.40]14124 -NACottin (Controls unexposed, disease free), 2015 1 Tags Adjustment   - No  - No 1.12[0.37; 3.40]14124 -NACottin (Controls unexposed, disease free), 2015 1 All studiesAll studies 1.12[0.37; 3.40]14124 -NACottin (Controls unexposed, disease free), 2015 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2835

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.12[0.37; 3.40]14124 -NACottin (Controls unexposed, disease free), 2015 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.64[0.19; 2.15]11124 -NACottin (Control exposed to other treatments), 2015 10.510.01.0