id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S2757 R3950 |
Zambelli-Weiner (Unexposed control, NOS), 2019 | Cleft palate | 1st trimester | nested case control | unexposed (general population or NOS) | Adjustment: Yes | 1.46 [0.81;2.65] | 11/889 1,068/114,174 | 1,079 | 889 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2852 R3875 |
Huybrechts (Control exposed to other treatment), 2018 | Cleft Palate | 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: Yes |
1.25 [0.89;1.75] excluded (control group) |
46/55,579 120/185,699 | 166 | 55,579 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2844 R3845 |
Huybrechts (Unexposed control), 2018 | Cleft Palate | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 1.20 [0.94;1.55] | 65/88,446 987/1,727,546 | 1,052 | 88,446 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2853 R3963 |
Parker, BDS study, 2018 | Cleft palate only | 1st trimester | case control | unexposed, sick | Adjustment: Yes | 0.50 [0.30;1.00] | 11/386 276/5,774 | 287 | 386 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2756 R3678 |
Parker, NBDPS study, 2018 | Cleft palate only | 1st trimester | case control | unexposed, sick | Adjustment: Yes | 1.60 [1.10;2.30] | 40/252 378/3,433 | 418 | 252 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2746 R3897 |
Pasternak, 2013 | Cleft palate | 1st trimester | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: No | 0.80 [0.04;16.67] C | 0/1,233 2/4,932 | 2 | 1,233 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2747 R3644 |
Anderka, 2012 | Cleft palate | 1st trimester | case control | unexposed, sick | Adjustment: Yes | 2.37 [1.18;4.76] | 11/55 514/4,479 | 525 | 55 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 6 studies | 1.26 [0.87;1.82] | 3,363 | 91,261 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Unexposed control, NOS; 2: Unexposed control;
Asymetry test p-value = 0.9279 (by Egger's regression)
slope=0.2628 (0.3444); intercept=-0.1480 (1.5373); t=0.0963; p=0.9279
excluded 2852