Ondansetron

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2856
R4588		 Shahraki, 2016 Cesarian section during pregnancy (anytime or not specified) randomized controlled trial exposed to other treatment, sick Adjustment: Randomisation 1.26 [0.67;2.37] C 28/88   27/100 55 88
ref
S2775
R3729		 Colvin, 2013 Caesarean during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.70 [1.30;2.20] 111/251   30,947/96,447 31,058 251
ref
Total 2 studies 1.63 [1.28;2.07] 31,113 339
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Shahraki, 2016Shahraki, 2016 1.26[0.67; 2.37]558815%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Colvin, 2013Colvin, 2013 1.70[1.30; 2.20]31,05825185%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.63[1.28; 2.07]31,1133390.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.70[1.31; 2.21]31,058251 -NAColvin, 2013 1 case control studiescase control studies 0 RCTRCT 1.26[0.67; 2.37]5588 -NAShahraki, 2016 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.70[1.31; 2.21]31,058251 -NAColvin, 2013 1 exposed to other treatment, sickexposed to other treatment, sick 1.26[0.67; 2.37]5588 -NAShahraki, 2016 1 Tags Adjustment   - No  - No 1.70[1.31; 2.21]31,058251 -NAColvin, 2013 1   - Randomisation  - Randomisation 1.26[0.67; 2.37]5588 -NAShahraki, 2016 1 All studiesAll studies 1.63[1.28; 2.07]31,1133390%NAShahraki, 2016 Colvin, 2013 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.70[1.31; 2.21]31,058251 -NAColvin, 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.26[0.67; 2.37]5588 -NAShahraki, 2016 10.510.01.0