Ondansetron

Patent ductus arterious

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2852
R3870		 Huybrechts (Control exposed to other treatment), 2018 Patent ductus arteriosus 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes 0.88 [0.66;1.16]
excluded (control group) 		62/55,579   170/185,699 232 55,579
ref
S2844
R3840		 Huybrechts (Unexposed control), 2018 Patent ductus arteriosus 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.90 [0.73;1.12] 88/88,446   1,587/1,727,546 1,675 88,446
ref
Total 1 studies 0.90 [0.73;1.11] 1,675 88,446
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Unexposed control), 2018Huybrechts, 2018 1 0.90[0.73; 1.12]1,67588,4460%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.90[0.73; 1.11]1,67588,446 -NAHuybrechts (Unexposed control), 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.90[0.73; 1.11]1,67588,446 -NAHuybrechts (Unexposed control), 2018 1 Tags Adjustment   - Yes  - Yes 0.90[0.73; 1.11]1,67588,446 -NAHuybrechts (Unexposed control), 2018 1 All studiesAll studies 0.90[0.73; 1.11]1,67588,446 -NAHuybrechts (Unexposed control), 2018 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2852

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.90[0.73; 1.11]1,67588,446 -NAHuybrechts (Unexposed control), 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.88[0.66; 1.17]23255,579 -NAHuybrechts (Control exposed to other treatment), 2018 10.510.01.0