Ondansetron

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2747
R3646		 Anderka, 2012 Neural tube defects 1st trimester case control unexposed, sick Adjustment: Yes 0.60 [0.21;1.68] 4/48   707/4,679 711 48
ref
Total 1 studies 0.60 [0.21;1.70] 711 48
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderka, 2012Anderka, 2012 0.60[0.21; 1.68]711480%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.60[0.21; 1.70]71148 -NAAnderka, 2012 1 Type of controls unexposed, sickunexposed, sick 0.60[0.21; 1.70]71148 -NAAnderka, 2012 1 Tags Adjustment   - Yes  - Yes 0.60[0.21; 1.70]71148 -NAAnderka, 2012 1 All studiesAll studies 0.60[0.21; 1.70]71148 -NAAnderka, 2012 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.60[0.21; 1.70]71148 -NAAnderka, 2012 10.510.01.0