Ondansetron

Ear malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2844
R3850		 Huybrechts (Unexposed control), 2018 Ear 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.67 [1.17;2.37] 34/88,446   416/1,727,546 450 88,446
ref
Total 1 studies 1.67 [1.17;2.38] 450 88,446
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Unexposed control), 2018Huybrechts, 2018 1 1.67[1.17; 2.37]45088,4460%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.67[1.17; 2.38]45088,446 -NAHuybrechts (Unexposed control), 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.67[1.17; 2.38]45088,446 -NAHuybrechts (Unexposed control), 2018 1 Tags Adjustment   - Yes  - Yes 1.67[1.17; 2.38]45088,446 -NAHuybrechts (Unexposed control), 2018 1 All studiesAll studies 1.67[1.17; 2.38]45088,446 -NAHuybrechts (Unexposed control), 2018 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.67[1.17; 2.38]45088,446 -NAHuybrechts (Unexposed control), 2018 10.510.01.0