Ondansetron

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2853
R3973		 Parker, BDS study, 2018 Anorectal atresia, stenosis 1st trimester case control unexposed, sick Adjustment: Yes 0.50 [0.20;1.40] 5/380   109/5,607 114 380
ref
S2756
R3690		 Parker, NBDPS study, 2018 Anorectal atresia, stenosis 1st trimester case control unexposed, sick Adjustment: Yes 0.90 [0.50;1.50] 15/268   541/7,039 556 268
ref
S2746
R3938		 Pasternak, 2013 Congenital absence, atresia and stenosis of anus without fistula 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.33 [0.05;32.76] C 0/1,233   1/4,932 1 1,233
ref
Total 3 studies 0.79 [0.49;1.27] 671 1,881
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parker, BDS study, 2018Parker, BDS study, 2018 0.50[0.20; 1.40]11438024%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 0.90[0.50; 1.50]55626874%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 1.33[0.05; 32.76]11,2332%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 0.79[0.49; 1.27]6711,8810.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 case control studiescase control studies 0.77[0.47; 1.28]6706486%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 unexposed, sickunexposed, sick 0.77[0.47; 1.28]6706486%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Tags Adjustment   - No  - No 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1   - Yes  - Yes 0.77[0.47; 1.28]6706486%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 All studiesAll studies 0.79[0.49; 1.27]6711,8810%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 Pasternak, 2013 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 unexposed, sick controlsunexposed, sick controls 0.77[0.47; 1.28]6706486%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.510.01.0