Ondansetron

Oesophageal atresia with or without tracheo-oesophageal fistula

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2756
R3692		 Parker, NBDPS study, 2018 Esophageal atresia 1st trimester case control unexposed, sick Adjustment: Yes 0.70 [0.40;1.30] 10/263   353/6,851 363 263
ref
S2746
R3942		 Pasternak, 2013 Atresia of oesophagus without fistula 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.33 [0.05;32.76] C 0/1,233   1/4,932 1 1,233
ref
Total 2 studies 0.71 [0.40;1.28] 364 1,496
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parker, NBDPS study, 2018Parker, NBDPS study, 2018 0.70[0.40; 1.30]36326397%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 1.33[0.05; 32.76]11,2333%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.71[0.40; 1.28]3641,4960.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 case control studiescase control studies 0.70[0.39; 1.26]363263 -NAParker, NBDPS study, 2018 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 unexposed, sickunexposed, sick 0.70[0.39; 1.26]363263 -NAParker, NBDPS study, 2018 1 Tags Adjustment   - No  - No 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1   - Yes  - Yes 0.70[0.39; 1.26]363263 -NAParker, NBDPS study, 2018 1 All studiesAll studies 0.71[0.40; 1.28]3641,4960%NAParker, NBDPS study, 2018 Pasternak, 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 unexposed, sick controlsunexposed, sick controls 0.70[0.39; 1.26]363263 -NAParker, NBDPS study, 2018 10.510.01.0