Ondansetron

Gastroschisis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2853
R3979		 Parker, BDS study, 2018 Gastroschisis 1st trimester case control unexposed, sick Adjustment: Yes 1.00 [0.60;1.80] 16/391   178/5,676 194 391
ref
S2756
R3696		 Parker, NBDPS study, 2018 Gastroschisis 1st trimester case control unexposed, sick Adjustment: Yes 0.80 [0.50;1.40] 17/270   746/8,244 763 270
ref
S2746
R3922		 Pasternak, 2013 Gastroschisis 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 0.80 [0.04;16.67] C 0/1,233   2/4,932 2 1,233
ref
Total 3 studies 0.89 [0.61;1.29] 959 1,894
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parker, BDS study, 2018Parker, BDS study, 2018 1.00[0.60; 1.80]19439146%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 0.80[0.50; 1.40]76327052%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.80[0.04; 16.67]21,2332%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 0.89[0.61; 1.29]9591,8940.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.80[0.04; 16.67]21,233 -NAPasternak, 2013 1 case control studiescase control studies 0.89[0.61; 1.29]9576610%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.80[0.04; 16.67]21,233 -NAPasternak, 2013 1 unexposed, sickunexposed, sick 0.89[0.61; 1.29]9576610%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Tags Adjustment   - No  - No 0.80[0.04; 16.67]21,233 -NAPasternak, 2013 1   - Yes  - Yes 0.89[0.61; 1.29]9576610%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 All studiesAll studies 0.89[0.61; 1.29]9591,8940%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 Pasternak, 2013 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.80[0.04; 16.67]21,233 -NAPasternak, 2013 1 unexposed, sick controlsunexposed, sick controls 0.89[0.61; 1.29]9576610%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.510.01.0