Ondansetron

Single ventricle

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2852
R3864		 Huybrechts (Control exposed to other treatment), 2018 Single ventricle defects 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes 0.55 [0.23;1.31]
excluded (control group) 		-/55,579   33/185,699 - 55,579
ref
S2844
R3834		 Huybrechts (Unexposed control), 2018 Single ventricle defects 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.56 [0.28;1.14] -/88,446   278/1,727,546 - 88,446
ref
S2756
R3700		 Parker, NBDPS study, 2018 Single ventricle 1st trimester case control unexposed, sick Adjustment: Yes 1.50 [0.70;3.30] 7/260   148/6,646 155 260
ref
Total 2 studies 0.90 [0.34;2.37] 155 88,706
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Unexposed control), 2018Huybrechts, 2018 1 0.56[0.28; 1.14]-88,44651%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 1.50[0.70; 3.30]15526049%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 71% 0.90[0.34; 2.37]15588,7060.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.56[0.28; 1.13]-88,446 -NAHuybrechts (Unexposed control), 2018 1 case control studiescase control studies 1.50[0.69; 3.26]155260 -NAParker, NBDPS study, 2018 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.56[0.28; 1.13]-88,446 -NAHuybrechts (Unexposed control), 2018 1 unexposed, sickunexposed, sick 1.50[0.69; 3.26]155260 -NAParker, NBDPS study, 2018 1 Tags Adjustment   - Yes  - Yes 0.90[0.34; 2.37]15588,70671%NAHuybrechts (Unexposed control), 2018 Parker, NBDPS study, 2018 2 All studiesAll studies 0.90[0.34; 2.37]15588,70671%NAHuybrechts (Unexposed control), 2018 Parker, NBDPS study, 2018 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2852

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.56[0.28; 1.13]26988,446 -NAHuybrechts (Unexposed control), 2018 1 unexposed, sick controlsunexposed, sick controls 1.50[0.69; 3.26]155260 -NAParker, NBDPS study, 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.55[0.23; 1.31]2455,579 -NAHuybrechts (Control exposed to other treatment), 2018 10.510.01.0