Ondansetron

Coarctation of aorta

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2853
R3988		 Parker, BDS study, 2018 Coarctation of the aorta 1st trimester case control unexposed, sick Adjustment: Yes 0.70 [0.40;1.20] 11/386   187/5,687 198 386
ref
S2756
R3705		 Parker, NBDPS study, 2018 Coarctation of the aorta 1st trimester case control unexposed, sick Adjustment: Yes 1.10 [0.80;1.70] 31/284   612/7,110 643 284
ref
S2746
R3912		 Pasternak, 2013 Coarctation of aorta 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 0.57 [0.03;11.07] C 0/1,233   3/4,932 3 1,233
ref
Total 3 studies 0.95 [0.69;1.29] 844 1,903
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parker, BDS study, 2018Parker, BDS study, 2018 0.70[0.40; 1.20]19838632%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 1.10[0.80; 1.70]64328467%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.57[0.03; 11.07]31,2331%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 0.95[0.69; 1.29]8441,9030.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.57[0.03; 11.07]31,233 -NAPasternak, 2013 1 case control studiescase control studies 0.92[0.60; 1.42]84167043%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.57[0.03; 11.07]31,233 -NAPasternak, 2013 1 unexposed, sickunexposed, sick 0.92[0.60; 1.42]84167043%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Tags Adjustment   - No  - No 0.57[0.03; 11.07]31,233 -NAPasternak, 2013 1   - Yes  - Yes 0.92[0.60; 1.42]84167043%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 All studiesAll studies 0.95[0.69; 1.29]8441,9030%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 Pasternak, 2013 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.57[0.03; 11.07]31,233 -NAPasternak, 2013 1 unexposed, sick controlsunexposed, sick controls 0.92[0.60; 1.42]84167043%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.510.01.0