Ondansetron

Hypoplastic left heart (HLH/HLHS)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2757
R3948		 Zambelli-Weiner (Unexposed control, NOS), 2019 Hypoplastic Left Heart Syndrome 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes 2.12 [0.87;5.13] 5/883   343/113,449 348 883
ref
S2853
R3987		 Parker, BDS study, 2018 Hypoplastic left heart syndrome 1st trimester case control unexposed, sick Adjustment: Yes 1.20 [0.60;2.40] 9/384   103/5,603 112 384
ref
S2756
R3704		 Parker, NBDPS study, 2018 Hypoplastic left heart syndrome 1st trimester case control unexposed, sick Adjustment: Yes 1.50 [0.90;2.50] 19/272   359/6,857 378 272
ref
Total 3 studies 1.49 [1.03;2.17] 838 1,539
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zambelli-Weiner (Unexposed control, NOS), 2019Zambelli-Weiner, 2019 1 2.12[0.87; 5.13]34888318%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, BDS study, 2018Parker, BDS study, 2018 1.20[0.60; 2.40]11238429%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 1.50[0.90; 2.50]37827253%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 1.49[1.03; 2.17]8381,5390.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.49[1.03; 2.17]8381,5390%NAZambelli-Weiner (Unexposed control, NOS), 2019 Parker, BDS study, 2018 Parker, NBDPS study, 2018 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.12[0.87; 5.15]348883 -NAZambelli-Weiner (Unexposed control, NOS), 2019 1 unexposed, sickunexposed, sick 1.39[0.92; 2.09]4906560%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Tags Adjustment   - Yes  - Yes 1.49[1.03; 2.17]8381,5390%NAZambelli-Weiner (Unexposed control, NOS), 2019 Parker, BDS study, 2018 Parker, NBDPS study, 2018 3 All studiesAll studies 1.49[1.03; 2.17]8381,5390%NAZambelli-Weiner (Unexposed control, NOS), 2019 Parker, BDS study, 2018 Parker, NBDPS study, 2018 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.12[0.87; 5.15]348883 -NAZambelli-Weiner (Unexposed control, NOS), 2019 1 unexposed, sick controlsunexposed, sick controls 1.39[0.92; 2.09]4906560%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.510.01.0