Ondansetron

Bilateral renal agenesis including Potter syndrome

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2853
R3984		 Parker, BDS study, 2018 Renal agenesis– dysgenesis 1st trimester case control unexposed, sick Adjustment: Yes 1.80 [1.10;3.00] 22/397   137/5,637 159 397
ref
S2746
R3924		 Pasternak, 2013 Renal agenesis 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 4.00 [0.25;64.04] C 1/1,233   1/4,932 2 1,233
ref
Total 2 studies 1.85 [1.13;3.02] 161 1,630
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parker, BDS study, 2018Parker, BDS study, 2018 1.80[1.10; 3.00]15939797%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 4.00[0.25; 64.04]21,2333%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.85[1.13; 3.02]1611,6300.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.00[0.25; 64.04]21,233 -NAPasternak, 2013 1 case control studiescase control studies 1.80[1.09; 2.97]159397 -NAParker, BDS study, 2018 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.00[0.25; 64.04]21,233 -NAPasternak, 2013 1 unexposed, sickunexposed, sick 1.80[1.09; 2.97]159397 -NAParker, BDS study, 2018 1 Tags Adjustment   - No  - No 4.00[0.25; 64.04]21,233 -NAPasternak, 2013 1   - Yes  - Yes 1.80[1.09; 2.97]159397 -NAParker, BDS study, 2018 1 All studiesAll studies 1.85[1.13; 3.02]1611,6300%NAParker, BDS study, 2018 Pasternak, 2013 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.00[0.25; 64.04]21,233 -NAPasternak, 2013 1 unexposed, sick controlsunexposed, sick controls 1.80[1.09; 2.97]159397 -NAParker, BDS study, 2018 10.510.01.0