Ondansetron

Atresia or stenosis of other parts of small intestine

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2853
R3976		 Parker, BDS study, 2018 Small intestinal atresia, stenosis 1st trimester case control unexposed, sick Adjustment: Yes 1.00 [0.60;1.90] 12/387   143/5,641 155 387
ref
S2756
R3693		 Parker, NBDPS study, 2018 Small intestinal atresia, stenosis 1st trimester case control unexposed, sick Adjustment: Yes 0.90 [0.40;1.90] 7/260   231/6,729 238 260
ref
S2746
R3940		 Pasternak, 2013 Congenital absence, atresia and stenosis of small intestine, part unspecified 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.33 [0.05;32.76] C 0/1,233   1/4,932 1 1,233
ref
Total 3 studies 0.97 [0.61;1.53] 394 1,880
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parker, BDS study, 2018Parker, BDS study, 2018 1.00[0.60; 1.90]15538763%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 0.90[0.40; 1.90]23826035%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 1.33[0.05; 32.76]11,2332%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 0.97[0.61; 1.53]3941,8800.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 case control studiescase control studies 0.96[0.61; 1.53]3936470%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 unexposed, sickunexposed, sick 0.96[0.61; 1.53]3936470%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Tags Adjustment   - No  - No 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1   - Yes  - Yes 0.96[0.61; 1.53]3936470%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 All studiesAll studies 0.97[0.61; 1.53]3941,8800%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 Pasternak, 2013 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 unexposed, sick controlsunexposed, sick controls 0.96[0.61; 1.53]3936470%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.510.01.0