Ondansetron

Severe congenital heart defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2852
R3863		 Huybrechts (Control exposed to other treatment), 2018 Conotruncal defects 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes 0.80 [0.55;1.17]
excluded (control group) 		33/55,579   144/185,699 177 55,579
ref
S2844
R3833		 Huybrechts (Unexposed control), 2018 Conotruncal defects 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.74 [0.57;0.96] 57/88,446   1,321/1,727,546 1,378 88,446
ref
S2853
R3989		 Parker, BDS study, 2018 Conotruncal anomalies 1st trimester case control unexposed, sick Adjustment: Yes 0.80 [0.60;1.10] 30/405   472/5,972 502 405
ref
Total 2 studies 0.76 [0.63;0.93] 1,880 88,851
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Unexposed control), 2018Huybrechts, 2018 1 0.74[0.57; 0.96]1,37888,44657%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, BDS study, 2018Parker, BDS study, 2018 0.80[0.60; 1.10]50240543%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.76[0.63; 0.93]1,88088,8510.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.74[0.57; 0.96]1,37888,446 -NAHuybrechts (Unexposed control), 2018 1 case control studiescase control studies 0.80[0.59; 1.08]502405 -NAParker, BDS study, 2018 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.74[0.57; 0.96]1,37888,446 -NAHuybrechts (Unexposed control), 2018 1 unexposed, sickunexposed, sick 0.80[0.59; 1.08]502405 -NAParker, BDS study, 2018 1 Tags Adjustment   - Yes  - Yes 0.76[0.63; 0.93]1,88088,8510%NAHuybrechts (Unexposed control), 2018 Parker, BDS study, 2018 2 All studiesAll studies 0.76[0.63; 0.93]1,88088,8510%NAHuybrechts (Unexposed control), 2018 Parker, BDS study, 2018 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2852

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.74[0.57; 0.96]1,37888,446 -NAHuybrechts (Unexposed control), 2018 1 unexposed, sick controlsunexposed, sick controls 0.80[0.59; 1.08]502405 -NAParker, BDS study, 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.80[0.55; 1.17]17755,579 -NAHuybrechts (Control exposed to other treatment), 2018 10.510.01.0