Ondansetron

Digestive system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2844
R3853		 Huybrechts (Unexposed control), 2018 Gastrointestinal 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.93 [0.85;1.02] 491/88,467   9,101/1,727,546 9,592 88,467
ref
S2746
R3901		 Pasternak, 2013 Digestive 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 0.31 [0.02;5.46] C 0/1,233   6/4,932 6 1,233
ref
Total 2 studies 0.93 [0.85;1.02] 9,598 89,700
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Unexposed control), 2018Huybrechts, 2018 1 0.93[0.85; 1.02]9,59288,467100%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.31[0.02; 5.46]61,2330%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.93[0.85; 1.02]9,59889,7000.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.93[0.85; 1.02]9,59889,7000%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.93[0.85; 1.02]9,59889,7000%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 Tags Adjustment   - No  - No 0.31[0.02; 5.46]61,233 -NAPasternak, 2013 1   - Yes  - Yes 0.93[0.85; 1.02]9,59288,467 -NAHuybrechts (Unexposed control), 2018 1 All studiesAll studies 0.93[0.85; 1.02]9,59889,7000%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.93[0.85; 1.02]9,59889,7000%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 20.510.01.0