Ondansetron

Urinary malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2757
R3956		 Zambelli-Weiner (Unexposed control, NOS), 2019 Renal collecting system anomalies 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes 1.24 [0.98;1.58] 69/947   7,803/120,909 7,872 947
ref
S2844
R3856		 Huybrechts (Unexposed control), 2018 Urinary 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.24 [0.73;2.14] 14/88,446   145/1,727,546 159 88,446
ref
S2853
R3968		 Parker, BDS study, 2018 Renal collecting system defects 1st trimester case control unexposed, sick Adjustment: Yes 1.20 [0.90;1.60] 74/449   743/6,241 817 449
ref
S2746
R3903		 Pasternak, 2013 Urinary 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.23 [0.40;3.78] C 4/1,233   13/4,932 17 1,233
ref
Total 4 studies 1.23 [1.03;1.46] 8,865 91,075
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zambelli-Weiner (Unexposed control, NOS), 2019Zambelli-Weiner, 2019 1 1.24[0.98; 1.58]7,87294752%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Huybrechts (Unexposed control), 2018Huybrechts, 2018 2 1.24[0.73; 2.14]15988,44610%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, BDS study, 2018Parker, BDS study, 2018 1.20[0.90; 1.60]81744936%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 1.23[0.40; 3.78]171,2332%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 0% 1.23[1.03; 1.46]8,86591,0750.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, NOS; 2: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.24[0.76; 2.01]17689,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 case control studiescase control studies 1.22[1.02; 1.47]8,6891,3960%NAZambelli-Weiner (Unexposed control, NOS), 2019 Parker, BDS study, 2018 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.24[1.00; 1.54]8,04890,6260%NAZambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Pasternak, 2013 3 unexposed, sickunexposed, sick 1.20[0.90; 1.60]817449 -NAParker, BDS study, 2018 1 Tags Adjustment   - No  - No 1.23[0.40; 3.78]171,233 -NAPasternak, 2013 1   - Yes  - Yes 1.23[1.03; 1.46]8,84889,8420%NAZambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Parker, BDS study, 2018 3 All studiesAll studies 1.23[1.03; 1.46]8,86591,0750%NAZambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Parker, BDS study, 2018 Pasternak, 2013 40.55.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.31.60.6870.000Zambelli-Weiner (Unexposed control, NOS), 2019Huybrechts (Unexposed control), 2018Parker, BDS study, 2018Pasternak, 2013

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.24[1.00; 1.54]8,04890,6260%NAZambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Pasternak, 2013 3 unexposed, sick controlsunexposed, sick controls 1.20[0.90; 1.60]817449 -NAParker, BDS study, 2018 10.510.01.0