Ondansetron

Therapeutic terminations of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2755
R3669		 Einarson (Control exposed to other antiemetics), 2004 Therapeutic abortions 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.00 [0.14;7.18] C
excluded (control group) 		2/176   2/176 4 176
ref
S2754
R3665		 Einarson (Unexposed control), 2004 Therapeutic abortions 1st trimester prospective cohort unexposed, disease free Adjustment: No 5.06 [0.24;106.12] C 2/176   0/176 2 176
ref
Total 1 studies 5.06 [0.24;106.12] 2 176
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Einarson (Unexposed control), 2004Einarson, 2004 1 5.06[0.24; 106.12]21760%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.06[0.24; 106.12]2176 -NAEinarson (Unexposed control), 2004 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.06[0.24; 106.12]2176 -NAEinarson (Unexposed control), 2004 1 Tags Adjustment   - No  - No 5.06[0.24; 106.12]2176 -NAEinarson (Unexposed control), 2004 1 All studiesAll studies 5.06[0.24; 106.12]2176 -NAEinarson (Unexposed control), 2004 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2755

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.06[0.24; 106.12]2176 -NAEinarson (Unexposed control), 2004 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.00[0.14; 7.18]4176 -NAEinarson (Control exposed to other antiemetics), 2004 10.510.01.0