Ondansetron

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3184
R5099		 Ozdemirci, 2014 Low birth weight (NOS) 1st trimester retrospective cohort exposed to other treatment, sick Adjustment: No 3.50 [0.38;31.93] C 4/100   1/85 5 100
ref
S2775
R3717		 Colvin, 2013 Birth weight <2500 g during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.30 [0.80;2.20] 30/263   7,078/98,062 7,108 263
ref
S2746
R3640		 Pasternak, 2013 Low birth weight (less than 2500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.76 [0.51;1.13] 73/1,784   265/7,136 338 1,784
ref
Total 3 studies 1.04 [0.61;1.77] 7,451 2,147
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ozdemirci, 2014Ozdemirci, 2014 3.50[0.38; 31.93]51005%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Colvin, 2013Colvin, 2013 1.30[0.80; 2.20]7,10826343%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.76[0.51; 1.13]3381,78451%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 50% 1.04[0.61; 1.77]7,4512,1470.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.04[0.61; 1.77]7,4512,14750%NAOzdemirci, 2014 Colvin, 2013 Pasternak, 2013 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.97[0.57; 1.64]7,4462,04763%NAColvin, 2013 Pasternak, 2013 2 exposed to other treatment, sickexposed to other treatment, sick 3.50[0.38; 31.93]5100 -NAOzdemirci, 2014 1 Tags Adjustment   - No  - No 3.50[0.38; 31.93]5100 -NAOzdemirci, 2014 1   - Yes  - Yes 0.97[0.57; 1.64]7,4462,04763%NAColvin, 2013 Pasternak, 2013 2 All studiesAll studies 1.04[0.61; 1.77]7,4512,14750%NAOzdemirci, 2014 Colvin, 2013 Pasternak, 2013 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.97[0.57; 1.64]7,4462,04763%NAColvin, 2013 Pasternak, 2013 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.50[0.38; 31.93]5100 -NAOzdemirci, 2014 10.510.01.0