Ondansetron

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2775
R3719		 Colvin, 2013 Proportion of optimal birth weight below 1 during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 0.80 [0.60;1.10] 115/263   49,708/98,062 49,823 263
ref
S2746
R3641		 Pasternak, 2013 Small for gestational age (gestational birth weight < 10th percentile) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.13 [0.89;1.44] 185/1,784   656/7,136 841 1,784
ref
Total 2 studies 0.96 [0.69;1.35] 50,664 2,047
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin, 2013Colvin, 2013 0.80[0.60; 1.10]49,82326346%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 1.13[0.89; 1.44]8411,78454%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 67% 0.96[0.69; 1.35]50,6642,0470.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.96[0.69; 1.35]50,6642,04767%NAColvin, 2013 Pasternak, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.96[0.69; 1.35]50,6642,04767%NAColvin, 2013 Pasternak, 2013 2 Tags Adjustment   - No  - No 0.80[0.59; 1.08]49,823263 -NAColvin, 2013 1   - Yes  - Yes 1.13[0.89; 1.44]8411,784 -NAPasternak, 2013 1 All studiesAll studies 0.96[0.69; 1.35]50,6642,04767%NAColvin, 2013 Pasternak, 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.96[0.69; 1.35]50,6642,04767%NAColvin, 2013 Pasternak, 2013 20.510.01.0