Renin-angiotensin system (ACEIs and/or ARBs) (versus unexposed) - Medication and Pregnancy KB

Renin-angiotensin system (ACEIs and/or ARBs) (versus unexposed) updated on 03-11-2025

Low Apgar score (< 7) (at 5 min)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17123 R71701	Van der Zande - ACE-Is and/or ARBs, 2024	Apgar score <7 at 5 min	during pregnancy (anytime or not specified)	prospective cohort	unexposed, sick	Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) Renin angiotensin: ARBs and/or ACEIs (Angiotensin II receptor blockers and/or Angiotensin-converting enzyme inhibitors)	0.67 [0.16;2.79] ^C	2/42 395/5,697	397	42		ref
					Total	1 studies	0.67 [0.16;2.79]		397	42
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded