Etanercept

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4994
R13077		 Drechsel, 2020 Neonatal death (0-7 days) 1st trimester prospective cohort unexposed, sick Adjustment: No 7.71 [0.14;414.30] C 0/9   0/66 0 9
ref
Total 1 studies 7.71 [0.14;414.30] 0 9
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Drechsel, 2020Drechsel, 2020 7.71[0.14; 414.30]090%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 7.71[0.14; 414.30]-9 -NADrechsel, 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 7.71[0.14; 414.30]-9 -NADrechsel, 2020 1 Tags Adjustment   - No  - No 7.71[0.14; 414.30]-9 -NADrechsel, 2020 1 All studiesAll studies 7.71[0.14; 414.30]-9 -NADrechsel, 2020 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 7.71[0.14; 414.30]-9 -NADrechsel, 2020 10.510.01.0