Etanercept

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4994
R13063		 Drechsel, 2020 Elective termination 1st trimester prospective cohort unexposed, sick Adjustment: No 0.46 [0.06;3.86] C 1/13   13/85 14 13
ref
S3011
R8684		 Carman (Control unexposed, disease free), 2017 Induced abortion (therapeutic, elective, and unspecified pregnancies) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 0.95 [0.63;1.43] C
excluded (control group) 		30/337   157/1,685 187 337
ref
S3010
R8683		 Carman (Control unexposed, sick), 2017 Induced abortion (therapeutic, elective, and unspecified pregnancies) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 1.04 [0.70;1.55] C 30/337   246/2,861 276 337
ref
S4998
R13105		 Hyrich, 2006 Elective first- trimester terminations 1st trimester retrospective cohort unexposed, sick Adjustment: No 4.41 [0.20;96.38] C 3/17   0/9 3 17
ref
Total 3 studies 1.03 [0.70;1.52] 293 367
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Drechsel, 2020Drechsel, 2020 0.46[0.06; 3.86]14133%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Carman (Control unexposed, sick), 2017Carman, 2017 1 1.04[0.70; 1.55]27633795%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Hyrich, 2006Hyrich, 2006 4.41[0.20; 96.38]3172%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 1.03[0.70; 1.52]2933670.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.70; 1.52]2933670%NADrechsel, 2020 Carman (Control unexposed, sick), 2017 Hyrich, 2006 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.03[0.70; 1.52]2933670%NADrechsel, 2020 Carman (Control unexposed, sick), 2017 Hyrich, 2006 3 Tags Adjustment   - No  - No 1.03[0.70; 1.52]2933670%NADrechsel, 2020 Carman (Control unexposed, sick), 2017 Hyrich, 2006 3 All studiesAll studies 1.03[0.70; 1.52]2933670%NADrechsel, 2020 Carman (Control unexposed, sick), 2017 Hyrich, 2006 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3011

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.95[0.63; 1.43]187337 -NACarman (Control unexposed, disease free), 2017 1 unexposed, sick controlsunexposed, sick controls 1.03[0.70; 1.52]2933670%NADrechsel, 2020 Carman (Control unexposed, sick), 2017 Hyrich, 2006 30.510.01.0