Etanercept

Macrosomia (> 4000g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4961
R13014		 De Lorenzo (Controls unexposed, disease free), 2020 Large for gestational age at least 1st trimester retrospective cohort unexposed, disease free excluded Adjustment: No 0.50 [0.02;10.48] C
excluded (control group) 		0/6   5/36 5 6
ref
S4960
R13008		 De Lorenzo (Controls unexposed, sick), 2020 Large for gestational age at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 5.73 [0.10;320.07] C 0/6   0/32 0 6
ref
Total 1 studies 5.73 [0.10;320.07] 0 6
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Lorenzo (Controls unexposed, sick), 2020De Lorenzo, 2020 1 5.73[0.10; 320.07]060%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.73[0.10; 320.07]-6 -NADe Lorenzo (Controls unexposed, sick), 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 5.73[0.10; 320.07]-6 -NADe Lorenzo (Controls unexposed, sick), 2020 1 Tags Adjustment   - No  - No 5.73[0.10; 320.07]-6 -NADe Lorenzo (Controls unexposed, sick), 2020 1 All studiesAll studies 5.73[0.10; 320.07]-6 -NADe Lorenzo (Controls unexposed, sick), 2020 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4961

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.50[0.02; 10.48]56 -NADe Lorenzo (Controls unexposed, disease free), 2020 1 unexposed, sick controlsunexposed, sick controls 5.73[0.10; 320.07]-6 -NADe Lorenzo (Controls unexposed, sick), 2020 10.510.01.0