Etanercept

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4894
R12924		 Broms (Controls exposed to other treatments), 2020 Small for gestation age (sex-specific weight by gestational age in the 10th percentile or below 2 standard deviations) 3 months (or more) before pregnancy or during pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.66 [1.30;2.11] C
excluded (control group) 		84/510   998/9,393 1,082 510
ref
S4895
R12929		 Broms (Controls unexposed, disease free), 2020 Small for gestation age (sex-specific weight by gestational age in the 10th percentile or below 2 standard deviations) 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed, disease free Adjustment: No 1.17 [0.89;1.54] C
excluded (exposition period) 		58/510   160,698/1,623,483 160,756 510
ref
S4961
R13013		 De Lorenzo (Controls unexposed, disease free), 2020 Small for gestational age at least 1st trimester retrospective cohort unexposed, disease free excluded Adjustment: No 5.50 [0.70;43.52] C
excluded (control group) 		2/6   3/36 5 6
ref
S4960
R13007		 De Lorenzo (Controls unexposed, sick), 2020 Small for gestational age at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 7.50 [0.81;69.08] C 2/6   2/32 4 6
ref
S4994
R13074		 Drechsel, 2020 Small for gestational age 1st trimester prospective cohort unexposed, sick Adjustment: No 1.49 [0.07;33.82] C 0/9   2/66 2 9
ref
Total 2 studies 4.36 [0.71;26.61] 6 15
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Lorenzo (Controls unexposed, sick), 2020De Lorenzo, 2020 1 7.50[0.81; 69.08]4666%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Drechsel, 2020Drechsel, 2020 1.49[0.07; 33.82]2934%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 4.36[0.71; 26.61]6150.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.36[0.71; 26.61]6150%NADe Lorenzo (Controls unexposed, sick), 2020 Drechsel, 2020 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 4.36[0.71; 26.61]6150%NADe Lorenzo (Controls unexposed, sick), 2020 Drechsel, 2020 2 Tags Adjustment   - No  - No 4.36[0.71; 26.61]6150%NADe Lorenzo (Controls unexposed, sick), 2020 Drechsel, 2020 2 All studiesAll studies 4.36[0.71; 26.61]6150%NADe Lorenzo (Controls unexposed, sick), 2020 Drechsel, 2020 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4894, 4961

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.50[0.70; 43.52]56 -NADe Lorenzo (Controls unexposed, disease free), 2020 1 unexposed, sick controlsunexposed, sick controls 4.36[0.71; 26.61]6150%NADe Lorenzo (Controls unexposed, sick), 2020 Drechsel, 2020 20.510.01.0