Infliximab

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3096
R4792		 Lichtenstein, 2018 Elective abortions 3 months or more before pregnancy or1st trimester excluded prospective cohort exposed to other treatment, sick Adjustment: No 4.64 [0.22;97.92] C
excluded (exposition period) 		2/99   0/90 2 99
ref
S5000
R13113		 Hyrich, 2006 Elective first- trimester terminations 1st trimester retrospective cohort unexposed, sick Adjustment: No 3.40 [0.05;219.14] C 0/3   0/9 0 3
ref
Total 1 studies 3.40 [0.05;219.14] 0 3
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hyrich, 2006Hyrich, 2006 3.40[0.05; 219.14]030%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.40[0.05; 219.14]-3 -NAHyrich, 2006 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 3.40[0.05; 219.14]-3 -NAHyrich, 2006 1 Tags Adjustment   - No  - No 3.40[0.05; 219.14]-3 -NAHyrich, 2006 1 All studiesAll studies 3.40[0.05; 219.14]-3 -NAHyrich, 2006 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 3.40[0.05; 219.14]-3 -NAHyrich, 2006 10.510.01.0