Infliximab

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4896
R12931		 Broms (Controls exposed to other treatments), 2020 Preterm birth (<37 weeks of gestation) 3 months (or more) before pregnancy or during pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 2.45 [1.71;3.51] C
excluded (control group) 		38/208   786/9,393 824 208
ref
S4897
R12936		 Broms (Controls unexposed, disease free), 2020 Preterm birth (<37 weeks of gestation) 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed, disease free Adjustment: No 4.62 [3.25;6.56] C
excluded (exposition period) 		38/208   74,981/1,623,489 75,019 208
ref
S4966
R13039		 De Lorenzo (Controls unexposed, disease free), 2020 Preterm birth at least 1st trimester retrospective cohort unexposed, disease free excluded Adjustment: No 2.68 [0.10;72.45] C
excluded (control group) 		0/3   2/36 2 3
ref
S4967
R13045		 De Lorenzo (Controls unexposed, sick), 2020 Preterm birth at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.63 [0.06;41.29] C 0/3   3/32 3 3
ref
S3096
R4799		 Lichtenstein, 2018 Preterm birth 3 months (or more) before pregnancy or during pregnancy excluded prospective cohort exposed to other treatment, sick Adjustment: No 0.80 [0.21;3.09] C
excluded (exposition period) 		4/81   5/82 9 81
ref
Total 1 studies 1.63 [0.06;41.29] 3 3
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Lorenzo (Controls unexposed, sick), 2020De Lorenzo, 2020 1 1.63[0.06; 41.29]330%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.63[0.06; 41.29]33 -NADe Lorenzo (Controls unexposed, sick), 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.63[0.06; 41.29]33 -NADe Lorenzo (Controls unexposed, sick), 2020 1 Tags Adjustment   - No  - No 1.63[0.06; 41.29]33 -NADe Lorenzo (Controls unexposed, sick), 2020 1 All studiesAll studies 1.63[0.06; 41.29]33 -NADe Lorenzo (Controls unexposed, sick), 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4896, 4966

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.68[0.10; 72.45]23 -NADe Lorenzo (Controls unexposed, disease free), 2020 1 unexposed, sick controlsunexposed, sick controls 1.63[0.06; 41.29]33 -NADe Lorenzo (Controls unexposed, sick), 2020 10.510.01.0