Infliximab

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4896
R12934		 Broms (Controls exposed to other treatments), 2020 Small for gestation age (sex-specific weight by gestational age in the 10th percentile or below 2 standard deviations) 3 months (or more) before pregnancy or during pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.31 [0.87;1.96] C
excluded (control group) 		28/208   998/9,393 1,026 208
ref
S4897
R12939		 Broms (Controls unexposed, disease free), 2020 Small for gestation age (sex-specific weight by gestational age in the 10th percentile or below 2 standard deviations) 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed, disease free Adjustment: No 1.42 [0.95;2.11] C
excluded (exposition period) 		28/208   160,698/1,623,483 160,726 208
ref
S4966
R13037		 De Lorenzo (Controls unexposed, disease free), 2020 Small for gestational age at least 1st trimester retrospective cohort unexposed, disease free excluded Adjustment: No 5.50 [0.38;79.87] C
excluded (control group) 		1/3   3/36 4 3
ref
S4967
R13043		 De Lorenzo (Controls unexposed, sick), 2020 Small for gestational age at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 7.50 [0.46;122.70] C 1/3   2/32 3 3
ref
Total 1 studies 7.50 [0.46;122.70] 3 3
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Lorenzo (Controls unexposed, sick), 2020De Lorenzo, 2020 1 7.50[0.46; 122.70]330%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 7.50[0.46; 122.70]33 -NADe Lorenzo (Controls unexposed, sick), 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 7.50[0.46; 122.70]33 -NADe Lorenzo (Controls unexposed, sick), 2020 1 Tags Adjustment   - No  - No 7.50[0.46; 122.70]33 -NADe Lorenzo (Controls unexposed, sick), 2020 1 All studiesAll studies 7.50[0.46; 122.70]33 -NADe Lorenzo (Controls unexposed, sick), 2020 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4896, 4966

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.50[0.38; 79.87]43 -NADe Lorenzo (Controls unexposed, disease free), 2020 1 unexposed, sick controlsunexposed, sick controls 7.50[0.46; 122.70]33 -NADe Lorenzo (Controls unexposed, sick), 2020 10.510.01.0