Adalimumab

Neonatal infections

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5069
R13220		 Chambers (Controls unexposed, disease free), 2019 Serious or opportunistic infections in the first year of life at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 1.77 [0.62;5.05]
excluded (control group) 		10/229   5/203 15 229
ref
S5068
R13205		 Chambers (Controls, sick), 2019 Serious or opportunistic infections in the first year of life at least 1st trimester prospective cohort unexposed, sick Adjustment: No 0.97 [0.34;2.77] 10/229   5/111 15 229
ref
S3078
R4730		 Vinet (Unexposed controls, disease free), 2018 Serious infections in the offspring (≥1 hospitalization with infection within the first 12 months of life) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 0.97 [0.24;3.94] C
excluded (control group) 		2/108   279/14,596 281 108
ref
S3079
R4731		 Vinet (Unexposed controls, sick), 2018 Serious infections in the offspring (≥1 hospitalization with infection within the first 12 months of life) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 0.93 [0.22;3.89] C 2/108   49/2,476 51 108
ref
Total 2 studies 0.96 [0.41;2.23] 66 337
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chambers (Controls, sick), 2019Chambers, 2019 1 0.97[0.34; 2.77]1522965%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Vinet (Unexposed controls, sick), 2018Vinet, 2018 2 0.93[0.22; 3.89]5110835%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.96[0.41; 2.23]663370.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls, sick; 2: Unexposed controls, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.96[0.41; 2.23]663370%NAChambers (Controls, sick), 2019 Vinet (Unexposed controls, sick), 2018 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.96[0.41; 2.23]663370%NAChambers (Controls, sick), 2019 Vinet (Unexposed controls, sick), 2018 2 Tags Adjustment   - No  - No 0.96[0.41; 2.23]663370%NAChambers (Controls, sick), 2019 Vinet (Unexposed controls, sick), 2018 2 All studiesAll studies 0.96[0.41; 2.23]663370%NAChambers (Controls, sick), 2019 Vinet (Unexposed controls, sick), 2018 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3078, 5069

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.43[0.62; 3.30]2963370%NAChambers (Controls unexposed, disease free), 2019 Vinet (Unexposed controls, disease free), 2018 2 unexposed, sick controlsunexposed, sick controls 0.96[0.41; 2.23]663370%NAChambers (Controls, sick), 2019 Vinet (Unexposed controls, sick), 2018 20.510.01.0