Adalimumab

Microcephaly / Small head circumference for gestational age

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5069
R13223		 Chambers (Controls unexposed, disease free), 2019 Head Circumference < 10th centile for Gestational Age At Birth at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: Yes 1.59 [0.84;3.03]
excluded (control group) 		29/182   17/165 46 182
ref
S5068
R13208		 Chambers (Controls, sick), 2019 Head Circumference < 10th centile for Gestational Age At Birth at least 1st trimester prospective cohort unexposed, sick Adjustment: Yes 1.46 [0.67;3.15] 29/182   10/90 39 182
ref
Total 1 studies 1.46 [0.67;3.17] 39 182
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chambers (Controls, sick), 2019Chambers, 2019 1 1.46[0.67; 3.15]391820%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.46[0.67; 3.17]39182 -NAChambers (Controls, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.46[0.67; 3.17]39182 -NAChambers (Controls, sick), 2019 1 Tags Adjustment   - Yes  - Yes 1.46[0.67; 3.17]39182 -NAChambers (Controls, sick), 2019 1 All studiesAll studies 1.46[0.67; 3.17]39182 -NAChambers (Controls, sick), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5069

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.59[0.84; 3.02]46182 -NAChambers (Controls unexposed, disease free), 2019 1 unexposed, sick controlsunexposed, sick controls 1.46[0.67; 3.17]39182 -NAChambers (Controls, sick), 2019 10.510.01.0