Adalimumab

Child/Infant head circumference abnormalities (> 1 year)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5069
R13226		 Chambers (Controls unexposed, disease free), 2019 Head Circumference < 10th centile at 1 year of age at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 17.24 [0.99;299.08] C
excluded (control group) 		9/161   0/138 9 161
ref
S5068
R13211		 Chambers (Controls, sick), 2019 Head Circumference < 10th centile at 1 year of age at least 1st trimester prospective cohort unexposed, sick Adjustment: No 2.10 [0.51;12.62] 9/161   2/75 11 161
ref
Total 1 studies 2.10 [0.42;10.45] 11 161
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chambers (Controls, sick), 2019Chambers, 2019 1 2.10[0.51; 12.62]111610%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.10[0.42; 10.45]11161 -NAChambers (Controls, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.10[0.42; 10.45]11161 -NAChambers (Controls, sick), 2019 1 Tags Adjustment   - No  - No 2.10[0.42; 10.45]11161 -NAChambers (Controls, sick), 2019 1 All studiesAll studies 2.10[0.42; 10.45]11161 -NAChambers (Controls, sick), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5069

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale17.24[0.99; 299.08]9161 -NAChambers (Controls unexposed, disease free), 2019 1 unexposed, sick controlsunexposed, sick controls 2.10[0.42; 10.45]11161 -NAChambers (Controls, sick), 2019 10.510.01.0