Adalimumab

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5069
R13218		 Chambers (Controls unexposed, disease free), 2019 Spontaneous abortion (< 20.0 gestational weeks) at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: Yes 4.27 [0.96;18.95]
excluded (control group) 		25/257   4/222 29 257
ref
S5068
R13203		 Chambers (Controls, sick), 2019 Spontaneous abortion (< 20.0 gestational weeks) at least 1st trimester prospective cohort unexposed, sick Adjustment: Yes 2.22 [0.67;7.29] 25/257   5/118 30 257
ref
S5001
R13115		 Hyrich, 2006 First-trimester miscarriages 1st trimester retrospective cohort unexposed, sick Adjustment: No 4.00 [0.17;95.76] C 1/3   1/9 2 3
ref
Total 2 studies 2.39 [0.78;7.30] 32 260
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chambers (Controls, sick), 2019Chambers, 2019 1 2.22[0.67; 7.29]3025788%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Hyrich, 2006Hyrich, 2006 4.00[0.17; 95.76]2312%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 2.39[0.78; 7.30]322600.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.39[0.78; 7.30]322600%NAChambers (Controls, sick), 2019 Hyrich, 2006 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.39[0.78; 7.30]322600%NAChambers (Controls, sick), 2019 Hyrich, 2006 2 Tags Adjustment   - No  - No 4.00[0.17; 95.76]23 -NAHyrich, 2006 1   - Yes  - Yes 2.22[0.67; 7.32]30257 -NAChambers (Controls, sick), 2019 1 All studiesAll studies 2.39[0.78; 7.30]322600%NAChambers (Controls, sick), 2019 Hyrich, 2006 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5069

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.27[0.96; 18.97]29257 -NAChambers (Controls unexposed, disease free), 2019 1 unexposed, sick controlsunexposed, sick controls 2.39[0.78; 7.30]322600%NAChambers (Controls, sick), 2019 Hyrich, 2006 20.510.01.0