Adalimumab

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5069
R13213
Chambers (Controls unexposed, disease free), 2019 Stillbirth (> 20.0 gestational weeks) at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 0.88 [0.02;44.29] C
excluded (control group)
0/257   0/225 0 257
ref
S5068
R13198
Chambers (Controls, sick), 2019 Stillbirth (> 20.0 gestational weeks) at least 1st trimester prospective cohort unexposed, sick Adjustment: No 0.47 [0.01;23.62] C 0/257   0/120 0 257
ref
S4069
R8602
Seirafi, 2014 Deaths in utero 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort unexposed, sick Adjustment: No 0.78 [0.03;19.62] C
excluded (exposition period)
0/42   1/99 1 42
ref
Total 1 studies 0.47 [0.01;23.62] 0 257
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chambers (Controls, sick), 2019Chambers, 2019 1 0.47[0.01; 23.62]02570%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.47[0.01; 23.62]-257 -NAChambers (Controls, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.47[0.01; 23.62]-257 -NAChambers (Controls, sick), 2019 1 Tags Adjustment   - No  - No 0.47[0.01; 23.62]-257 -NAChambers (Controls, sick), 2019 1 All studiesAll studies 0.47[0.01; 23.62]-257 -NAChambers (Controls, sick), 2019 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5069

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.88[0.02; 44.29]-257 -NAChambers (Controls unexposed, disease free), 2019 1 unexposed, sick controlsunexposed, sick controls Out of scale0.47[0.01; 23.62]-257 -NAChambers (Controls, sick), 2019 10.510.01.0