Adalimumab

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4893
R12912		 Broms (Controls exposed to other treatments), 2020 Preterm birth (<37 weeks of gestation) 3 months (or more) before pregnancy or during pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.45 [0.98;2.13] C
excluded (control group) 		30/257   786/9,393 816 257
ref
S4892
R12907		 Broms (Controls unexposed, disease free), 2020 Preterm birth (<37 weeks of gestation) 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed, disease free Adjustment: No 2.73 [1.86;3.99] C
excluded (exposition period) 		30/257   74,981/1,623,489 75,011 257
ref
S5066
R13189		 De Lorenzo (Controls unexposed, disease free), 2020 Preterm birth at least 1st trimester retrospective cohort unexposed, disease free excluded Adjustment: No 4.47 [0.14;140.56] C
excluded (control group) 		0/2   2/36 2 2
ref
S5067
R13195		 De Lorenzo (Controls unexposed, sick), 2020 Preterm birth at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 2.71 [0.09;80.34] C 0/2   3/32 3 2
ref
S5069
R13219		 Chambers (Controls unexposed, disease free), 2019 Preterm delivery (<37.0 gestational weeks) at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: Yes 2.59 [1.22;5.50]
excluded (control group) 		24/213   10/203 34 213
ref
S5068
R13204		 Chambers (Controls, sick), 2019 Preterm delivery (<37.0 gestational weeks) at least 1st trimester prospective cohort unexposed, sick Adjustment: Yes 0.82 [0.66;7.20] 24/213   14/100 38 213
ref
S3006
R4292		 Hoxha, 2017 Premature birth (<37 weeks of gestation) 1st trimester prospective cohort unexposed, sick Adjustment: No 9.00 [0.29;275.58] C 1/5   0/11 1 5
ref
Total 3 studies 1.17 [0.40;3.41] 42 220
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Lorenzo (Controls unexposed, sick), 2020De Lorenzo, 2020 1 2.71[0.09; 80.34]3210%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Chambers (Controls, sick), 2019Chambers, 2019 2 0.82[0.66; 7.20]3821380%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Hoxha, 2017Hoxha, 2017 9.00[0.29; 275.58]1510%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 1.17[0.40; 3.41]422200.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.17[0.40; 3.41]422200%NADe Lorenzo (Controls unexposed, sick), 2020 Chambers (Controls, sick), 2019 Hoxha, 2017 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.17[0.40; 3.41]422200%NADe Lorenzo (Controls unexposed, sick), 2020 Chambers (Controls, sick), 2019 Hoxha, 2017 3 Tags Adjustment   - No  - No 4.91[0.44; 54.56]470%NADe Lorenzo (Controls unexposed, sick), 2020 Hoxha, 2017 2   - Yes  - Yes 0.82[0.25; 2.71]38213 -NAChambers (Controls, sick), 2019 1 All studiesAll studies 1.17[0.40; 3.41]422200%NADe Lorenzo (Controls unexposed, sick), 2020 Chambers (Controls, sick), 2019 Hoxha, 2017 30.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5069, 4893, 5066

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.66[1.27; 5.54]362150%NADe Lorenzo (Controls unexposed, disease free), 2020 Chambers (Controls unexposed, disease free), 2019 2 unexposed, sick controlsunexposed, sick controls 1.17[0.40; 3.41]422200%NADe Lorenzo (Controls unexposed, sick), 2020 Chambers (Controls, sick), 2019 Hoxha, 2017 30.510.01.0