TNF-alpha inhibitors

Jaundice / Icterus

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3069
R8740
Agosti, 2015 Jaundice during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 1.00 [0.06;16.97] C 1/24   1/24 2 24
ref
S3037
R4575
Seirafi, 2014 Neonatal jaundice 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort unexposed, sick Adjustment: No before conception and/or during pregnancy 1.02 [0.22;4.67] C
excluded (exposition period)
4/118   3/90 7 118
ref
Total 1 studies 1.00 [0.06;16.97] 2 24
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Agosti, 2015Agosti, 2015 1.00[0.06; 16.97]2240%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.52.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.00[0.06; 16.97]224 -NAAgosti, 2015 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.00[0.06; 16.97]224 -NAAgosti, 2015 1 Tags Adjustment   - No  - No 1.00[0.06; 16.97]224 -NAAgosti, 2015 1 All studiesAll studies 1.00[0.06; 16.97]224 -NAAgosti, 2015 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.00[0.06; 16.97]224 -NAAgosti, 2015 10.510.01.0