TNF-alpha inhibitors

ASD (Autism spectrum disorder): Diagnosis/Risk

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3072
R53479		 Duricova, 2019 Autism during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free Adjustment: No 0.96 [0.06;15.62] C 1/72   1/69 2 72
ref
Total 1 studies 0.96 [0.06;15.62] 2 72
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Duricova, 2019Duricova, 2019 0.96[0.06; 15.62]2720%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.96[0.06; 15.62]272 -NADuricova, 2019 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.96[0.06; 15.62]272 -NADuricova, 2019 1 Tags Adjustment   - No  - No 0.96[0.06; 15.62]272 -NADuricova, 2019 1 All studiesAll studies 0.96[0.06; 15.62]272 -NADuricova, 2019 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.96[0.06; 15.62]272 -NADuricova, 2019 10.510.01.0