TNF-alpha inhibitors

Chromosomal abnormalities

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3194
R5167		 Bröms a (Controls unexposed, disease free), 2016 Chromosomal 3 months or more before pregnancy or1st trimester population based cohort retrospective unexposed, disease free excluded Adjustment: No 1.85 [0.46;7.40] C
excluded (control group) 		2/683   1,985/1,250,192 1,987 683
ref
S3193
R5145		 Bröms a (Controls unexposed, sick), 2016 Chromosomal 3 months or more before pregnancy or1st trimester excluded population based cohort retrospective unexposed, sick Adjustment: Yes 2.17 [0.35;7.26]
excluded (exposition period) 		2/683   32/21,549 34 683
ref
S2888
R4107		 Weber-Schoendorfer, 2015 Genetic anomalies 1st trimester prospective cohort unexposed, disease free Adjustment: Yes 1.80 [0.50;6.90] 4/421   11/1,391 15 421
ref
Total 1 studies 1.80 [0.48;6.69] 15 421
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Weber-Schoendorfer, 2015Weber-Schoendorfer, 2015 1.80[0.50; 6.90]154210%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.80[0.48; 6.69]15421 -NAWeber-Schoendorfer, 2015 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.80[0.48; 6.69]15421 -NAWeber-Schoendorfer, 2015 1 Tags Adjustment   - Yes  - Yes 1.80[0.48; 6.69]15421 -NAWeber-Schoendorfer, 2015 1 All studiesAll studies 1.80[0.48; 6.69]15421 -NAWeber-Schoendorfer, 2015 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3194

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.80[0.48; 6.69]15421 -NAWeber-Schoendorfer, 2015 10.510.01.0