TNF-alpha inhibitors

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4103
R8786		 Lichtenstein - infliximab, 2018 Spontaneous abortions (NOS) 3 months (or more) before pregnancy or during pregnancy excluded prospective cohort exposed to other treatment, sick Adjustment: No 1.98 [0.80;4.87] C
excluded (exposition period) 		16/99   8/90 24 99
ref
S3009
R4306		 Hoxha, 2017 Spontaneous abortion (NOS) 1st trimester prospective cohort unexposed, sick Adjustment: No 0.24 [0.03;1.73] C 2/24   3/11 5 24
ref
S13735
R53501		 Komoto, 2016 Spontaneous abortion (NOS) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 14.08 [0.72;276.19] C 4/24   0/31 4 24
ref
S3014
R4501		 Casanova, 2013 Spontaneous abortion (NOS) 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort exposed to other treatment, sick Adjustment: No 0.72 [0.29;1.77] C
excluded (exposition period) 		6/66   39/318 45 66
ref
S3017
R4517		 Schnitzler (Controls unexposed, disease free), 2011 Abortions (including elective abortions) 3 months (or more) before pregnancy or during pregnancy prospective cohort unexposed, disease free excluded Adjustment: No before conception and/or during pregnancy 1.88 [0.67;5.26] C
excluded (control group) 		10/42   8/56 18 42
ref
S3018
R4522		 Schnitzler (Unexposed control, sick), 2011 Abortions (including elective abortions) 3 months (or more) before pregnancy or during pregnancy excluded prospective cohort unexposed, sick Adjustment: No before conception and/or during pregnancy 1.56 [0.62;3.95] C
excluded (exposition period) 		10/42   13/78 23 42
ref
Total 2 studies 1.57 [0.03;83.21] 9 48
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hoxha, 2017Hoxha, 2017 0.24[0.03; 1.73]52454%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Komoto, 2016Komoto, 2016 14.08[0.72; 276.19]42446%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 80% 1.57[0.03; 83.21]9480.250.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.57[0.03; 83.21]94880%NAHoxha, 2017 Komoto, 2016 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.57[0.03; 83.21]94880%NAHoxha, 2017 Komoto, 2016 2 Tags Adjustment   - No  - No 1.57[0.03; 83.21]94880%NAHoxha, 2017 Komoto, 2016 2 All studiesAll studies 1.57[0.03; 83.21]94880%NAHoxha, 2017 Komoto, 2016 20.150.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3017

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.57[0.03; 83.21]94880%NAHoxha, 2017 Komoto, 2016 20.510.01.0