TNF-alpha inhibitors

Neonatal disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4103
R8789		 Lichtenstein - infliximab, 2018 Neonatal problem 3 months (or more) before pregnancy or during pregnancy excluded prospective cohort exposed to other treatment, sick Adjustment: No 0.70 [0.21;2.32] C
excluded (exposition period) 		5/81   7/82 12 81
ref
S4074
R8627		 Cooper, 2014 Neonatal complications 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No 1.80 [0.51;6.40] C 4/56   7/171 11 56
ref
Total 1 studies 1.80 [0.51;6.40] 11 56
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cooper, 2014Cooper, 2014 1.80[0.51; 6.40]11560%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.80[0.51; 6.40]1156 -NACooper, 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.80[0.51; 6.40]1156 -NACooper, 2014 1 Tags Adjustment   - No  - No 1.80[0.51; 6.40]1156 -NACooper, 2014 1 All studiesAll studies 1.80[0.51; 6.40]1156 -NACooper, 2014 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.80[0.51; 6.40]1156 -NACooper, 2014 10.510.01.0