Leflunomide

Microcephaly / Small head circumference for gestational age

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2970
R4186		 Chambers (Unexposed control, disease free), 2010 Infants head circumference ≤10th centile at birth 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 1.31 [0.36;4.78] C
excluded (control group) 		5/56   5/72 10 56
ref
S2969
R4173		 Chambers (Unexposed control, sick), 2010 Infants head circumference ≤10th centile at birth 1st trimester prospective cohort unexposed, sick Adjustment: No 0.62 [0.21;1.84] C 5/56   13/95 18 56
ref
Total 1 studies 0.62 [0.21;1.84] 18 56
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chambers (Unexposed control, sick), 2010Chambers, 2010 1 0.62[0.21; 1.84]18560%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.62[0.21; 1.84]1856 -NAChambers (Unexposed control, sick), 2010 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.62[0.21; 1.84]1856 -NAChambers (Unexposed control, sick), 2010 1 Tags Adjustment   - No  - No 0.62[0.21; 1.84]1856 -NAChambers (Unexposed control, sick), 2010 1 All studiesAll studies 0.62[0.21; 1.84]1856 -NAChambers (Unexposed control, sick), 2010 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2970

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.31[0.36; 4.78]1056 -NAChambers (Unexposed control, disease free), 2010 1 unexposed, sick controlsunexposed, sick controls 0.62[0.21; 1.84]1856 -NAChambers (Unexposed control, sick), 2010 10.510.01.0