Leflunomide

Minor congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2970
R4182		 Chambers (Unexposed control, disease free), 2010 Minor structural anomalies (>2) 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 2.15 [1.00;4.63] C
excluded (control group) 		24/51   19/65 43 51
ref
S2969
R4169		 Chambers (Unexposed control, sick), 2010 Minor structural anomalies (>2) 1st trimester prospective cohort unexposed, sick Adjustment: No 1.87 [0.92;3.79] C 24/51   29/90 53 51
ref
Total 1 studies 1.87 [0.92;3.79] 53 51
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chambers (Unexposed control, sick), 2010Chambers, 2010 1 1.87[0.92; 3.79]53510%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.87[0.92; 3.79]5351 -NAChambers (Unexposed control, sick), 2010 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.87[0.92; 3.79]5351 -NAChambers (Unexposed control, sick), 2010 1 Tags Adjustment   - No  - No 1.87[0.92; 3.79]5351 -NAChambers (Unexposed control, sick), 2010 1 All studiesAll studies 1.87[0.92; 3.79]5351 -NAChambers (Unexposed control, sick), 2010 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2970

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.15[1.00; 4.63]4351 -NAChambers (Unexposed control, disease free), 2010 1 unexposed, sick controlsunexposed, sick controls 1.87[0.92; 3.79]5351 -NAChambers (Unexposed control, sick), 2010 10.510.01.0