Leflunomide

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2900
R4097		 Bérard, 2018 Spontaneous abortion (< 22 weeks) during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes 1.09 [0.90;1.32] 11/49   17,723/106,353 17,734 49
ref
S2970
R4174		 Chambers (Unexposed control, disease free), 2010 Spontaneous abortion (NOS) 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 2.14 [0.49;9.35] C
excluded (control group) 		5/61   3/75 8 61
ref
S2969
R4157		 Chambers (Unexposed control, sick), 2010 Spontaneous abortion (NOS) 1st trimester prospective cohort unexposed, sick Adjustment: No 1.06 [0.33;3.38] C 5/63   8/106 13 63
ref
Total 2 studies 1.09 [0.90;1.32] 17,747 112
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard, 2018Bérard, 2018 1.09[0.90; 1.32]17,7344997%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Chambers (Unexposed control, sick), 2010Chambers, 2010 1 1.06[0.33; 3.38]13633%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.09[0.90; 1.32]17,7471120.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.06[0.33; 3.38]1363 -NAChambers (Unexposed control, sick), 2010 1 case control studiescase control studies 1.09[0.90; 1.32]17,73449 -NABérard, 2018 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.09[0.90; 1.32]17,73449 -NABérard, 2018 1 unexposed, sickunexposed, sick 1.06[0.33; 3.38]1363 -NAChambers (Unexposed control, sick), 2010 1 Tags Adjustment   - No  - No 1.06[0.33; 3.38]1363 -NAChambers (Unexposed control, sick), 2010 1   - Yes  - Yes 1.09[0.90; 1.32]17,73449 -NABérard, 2018 1 All studiesAll studies 1.09[0.90; 1.32]17,7471120%NABérard, 2018 Chambers (Unexposed control, sick), 2010 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2970

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.10[0.91; 1.33]17,7421100%NABérard, 2018 Chambers (Unexposed control, disease free), 2010 2 unexposed, sick controlsunexposed, sick controls 1.06[0.33; 3.38]1363 -NAChambers (Unexposed control, sick), 2010 10.510.01.0