Leflunomide

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2900
R4096		 Bérard, 2018 Low birth weight (< 2500g) 2nd and/or 3rd trimester nested case control unexposed (general population or NOS) Adjustment: Yes 1.06 [0.90;1.25] -/-   0/- - -
ref
S4080
R8676		 Karadag, 2013 Low birth weight early pregnancy retrospective cohort unexposed, sick Adjustment: No 0.84 [0.03;23.59] C 0/3   2/13 2 3
ref
Total 2 studies 1.06 [0.90;1.25] 2 3
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard, 2018Bérard, 2018 1.06[0.90; 1.25]--100%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Karadag, 2013Karadag, 2013 0.84[0.03; 23.59]230%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.06[0.90; 1.25]230.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.84[0.03; 23.59]23 -NAKaradag, 2013 1 case control studiescase control studies 1.06[0.90; 1.25]-- -NABérard, 2018 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.06[0.90; 1.25]-- -NABérard, 2018 1 unexposed, sickunexposed, sick 0.84[0.03; 23.59]23 -NAKaradag, 2013 1 Tags Adjustment   - No  - No 0.84[0.03; 23.59]23 -NAKaradag, 2013 1   - Yes  - Yes 1.06[0.90; 1.25]-- -NABérard, 2018 1 All studiesAll studies 1.06[0.90; 1.25]230%NABérard, 2018 Karadag, 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.06[0.90; 1.25]-- -NABérard, 2018 1 unexposed, sick controlsunexposed, sick controls 0.84[0.03; 23.59]23 -NAKaradag, 2013 10.510.01.0