Anakinra

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4962
R13023		 De Lorenzo (Controls unexposed, disease free), 2020 Malformations at least 1st trimester retrospective cohort unexposed, disease free excluded Adjustment: No 4.60 [0.15;144.69] C
excluded (control group) 		0/3   1/36 1 3
ref
S4963
R13029		 De Lorenzo (Controls unexposed, sick), 2020 Malformations at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 12.60 [0.20;780.42] C 0/3   0/32 0 3
ref
Total 1 studies 12.60 [0.20;780.42] 0 3
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Lorenzo (Controls unexposed, sick), 2020De Lorenzo, 2020 1 12.60[0.20; 780.42]030%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 12.60[0.20; 780.42]-3 -NADe Lorenzo (Controls unexposed, sick), 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 12.60[0.20; 780.42]-3 -NADe Lorenzo (Controls unexposed, sick), 2020 1 Tags Adjustment   - No  - No 12.60[0.20; 780.42]-3 -NADe Lorenzo (Controls unexposed, sick), 2020 1 All studiesAll studies 12.60[0.20; 780.42]-3 -NADe Lorenzo (Controls unexposed, sick), 2020 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4962

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.60[0.15; 144.69]13 -NADe Lorenzo (Controls unexposed, disease free), 2020 1 unexposed, sick controlsunexposed, sick controls Out of scale12.60[0.20; 780.42]-3 -NADe Lorenzo (Controls unexposed, sick), 2020 10.510.01.0