Teriflunomide

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3148
R4962		 Barataud-Reilhac A (Control exposed to IFN or GLA), 2019 Neonatal intensive care unit admission or reanimation during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.60 [0.04;10.26] C
excluded (control group) 		0/23   19/546 19 23
ref
S3147
R4955		 Barataud-Reilhac A (Control unexposed, sick), 2019 Neonatal intensive care unit admission or reanimation during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 0.50 [0.03;8.44] C 0/23   48/1,149 48 23
ref
Total 1 studies 0.50 [0.03;8.44] 48 23
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Barataud-Reilhac A (Control unexposed, sick), 2019Barataud-Reilhac A, 2019 1 0.50[0.03; 8.44]48230%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.50[0.03; 8.44]4823 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.50[0.03; 8.44]4823 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 Tags Adjustment   - No  - No 0.50[0.03; 8.44]4823 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 All studiesAll studies 0.50[0.03; 8.44]4823 -NABarataud-Reilhac A (Control unexposed, sick), 2019 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3148

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.50[0.03; 8.44]4823 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.60[0.04; 10.26]1923 -NABarataud-Reilhac A (Control exposed to IFN or GLA), 2019 10.510.01.0