Teriflunomide

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3148
R4960		 Barataud-Reilhac A (Control exposed to IFN or GLA), 2019 Spontaneous abortion during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.92 [0.21;3.97] C
excluded (control group) 		2/47   31/673 33 47
ref
S3147
R4953		 Barataud-Reilhac A (Control unexposed, sick), 2019 Spontaneous abortion during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 0.82 [0.20;3.44] C 2/47   79/1,538 81 47
ref
Total 1 studies 0.82 [0.20;3.44] 81 47
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Barataud-Reilhac A (Control unexposed, sick), 2019Barataud-Reilhac A, 2019 1 0.82[0.20; 3.44]81470%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.82[0.20; 3.44]8147 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.82[0.20; 3.44]8147 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 Tags Adjustment   - No  - No 0.82[0.20; 3.44]8147 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 All studiesAll studies 0.82[0.20; 3.44]8147 -NABarataud-Reilhac A (Control unexposed, sick), 2019 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3148

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.82[0.20; 3.44]8147 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.92[0.21; 3.97]3347 -NABarataud-Reilhac A (Control exposed to IFN or GLA), 2019 10.510.01.0