Teriflunomide

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3148
R4963		 Barataud-Reilhac A (Control exposed to IFN or GLA), 2019 Low birth weight (< 2500g) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.52 [0.44;5.30] C
excluded (control group) 		3/23   49/546 52 23
ref
S3147
R4956		 Barataud-Reilhac A (Control unexposed, sick), 2019 Low birth weight (< 2500g) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 1.66 [0.49;5.70] C 3/23   95/1,149 98 23
ref
Total 1 studies 1.66 [0.49;5.70] 98 23
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Barataud-Reilhac A (Control unexposed, sick), 2019Barataud-Reilhac A, 2019 1 1.66[0.49; 5.70]98230%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.66[0.49; 5.70]9823 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.66[0.49; 5.70]9823 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 Tags Adjustment   - No  - No 1.66[0.49; 5.70]9823 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 All studiesAll studies 1.66[0.49; 5.70]9823 -NABarataud-Reilhac A (Control unexposed, sick), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3148

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.66[0.49; 5.70]9823 -NABarataud-Reilhac A (Control unexposed, sick), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.52[0.44; 5.30]5223 -NABarataud-Reilhac A (Control exposed to IFN or GLA), 2019 10.510.01.0