Vedolizumab

Neonatal infections

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4950
R12982		 Moens (Controls exposed to TNFi), 2020 Infections during the first year of life at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.42 [0.10;1.71] C
excluded (control group) 		3/64   7/67 10 64
ref
S4946
R12976		 Moens (Controls unexposed, sick), 2020 Infections during the first year of life at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.37 [0.09;1.48] C 3/64   7/59 10 64
ref
Total 1 studies 0.37 [0.09;1.48] 10 64
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Moens (Controls unexposed, sick), 2020Moens, 2020 1 0.37[0.09; 1.48]10640%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.37[0.09; 1.48]1064 -NAMoens (Controls unexposed, sick), 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.37[0.09; 1.48]1064 -NAMoens (Controls unexposed, sick), 2020 1 Tags Adjustment   - No  - No 0.37[0.09; 1.48]1064 -NAMoens (Controls unexposed, sick), 2020 1 All studiesAll studies 0.37[0.09; 1.48]1064 -NAMoens (Controls unexposed, sick), 2020 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4950

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.37[0.09; 1.48]1064 -NAMoens (Controls unexposed, sick), 2020 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.42[0.10; 1.71]1064 -NAMoens (Controls exposed to TNFi), 2020 10.510.01.0